There are alot of articles, blogs, and reports on Talc based powders not being safe and that they may cause cancer. With that being said, I steer clear of any such products and try to use the best all natural and organic products on my baby. I found MADE OF with prides their brand on being the only certified organic that is also vegan, gluten-free, soy-free, nut-free group of products. MADE OF products, including their Talc-free baby powder are great. They even have samples available for a small fee on their website.